Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargeteNOS

Cell permeable: yes

General description

Caveolin-1 scaffolding domain peptide (C1-SD_82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). This peptide is reported to block eNOS activity and cellular NO release in vitro and reduce inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signaling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD_82-101 sequence.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA102, 761.Williams, T.M., et al. 2004. J. Biol. Chem.279, 51630.Gratton, J.P., et al. 2003. Cancer Cell4, 31.Sukumaran, S.K., et al. 2002. J. Biol. Chem.277, 50716.Liu, J., et al. 2002. J. Biol. Chem.277, 10661.Bucci, M., et al. 2000. Nat. Med.6, 1362.Okamoto, T., et al. 1998. J. Biol. Chem.273, 5419.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH

Warning

Toxicity: Carcinogenic / Teratogenic (D)