Caveolin-1 Scaffolding Domain Peptide; Cell-permeable

Code: 219482-1MG D2-231

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargeteNOS

Cell permeable: yes

General description<...


read more

Your Price
€307.50 1MG
€378.23 inc. VAT

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargeteNOS

Cell permeable: yes

General description

Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). This peptide is reported to block eNOS activity and cellular NO release in vitro and reduce inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signaling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA102, 761.Williams, T.M., et al. 2004. J. Biol. Chem.279, 51630.Gratton, J.P., et al. 2003. Cancer Cell4, 31.Sukumaran, S.K., et al. 2002. J. Biol. Chem.277, 50716.Liu, J., et al. 2002. J. Biol. Chem.277, 10661.Bucci, M., et al. 2000. Nat. Med.6, 1362.Okamoto, T., et al. 1998. J. Biol. Chem.273, 5419.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH

Warning

Toxicity: Carcinogenic / Teratogenic (D)

assay≥95% (HPLC)
colorwhite
formlyophilized solid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inwet ice
solubilityDMSO: 2 mg/mL
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.−20°C
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.