Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargeteNOS
Cell permeable: yes
General description
Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). This peptide is reported to block eNOS activity and cellular NO release in vitro and reduce inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signaling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA102, 761.Williams, T.M., et al. 2004. J. Biol. Chem.279, 51630.Gratton, J.P., et al. 2003. Cancer Cell4, 31.Sukumaran, S.K., et al. 2002. J. Biol. Chem.277, 50716.Liu, J., et al. 2002. J. Biol. Chem.277, 10661.Bucci, M., et al. 2000. Nat. Med.6, 1362.Okamoto, T., et al. 1998. J. Biol. Chem.273, 5419.
Packaging
1 mg in Plastic ampoule
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sequence
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
Warning
Toxicity: Carcinogenic / Teratogenic (D)
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